Parasitic worms and tuberculosis (TB) are involved in one of the most geographically extensive of pathogen interactions, and during coinfection worms can exacerbate TB disease outcomes.
In this case, negative interactions between two pathogens could emerge even in the absence of concurrent infection. It is also possible that host immune responses to a pathogen, shaped by historical evolutionary interactions between host and pathogen, may modify host immune defenses in ways that have repercussions for other pathogens. 118, issue 3, 2021, e2015080118.Ībstract: Pathogen interactions arising during coinfection can exacerbate disease severity, for example when the immune response mounted against one pathogen negatively affects defense of another. “ Natural Resistance to Worms Exacerbates Bovine Tuberculosis Severity Independently of Worm Coinfection.” Proceedings of the National Academy of Sciences of the United States of America, vol. Budischak, Peter Buss, Mauricio Seguel, Gordon Luikart, Anna E. Our results reveal a function for piriform cortex in spatial cognition and suggest that it is well-suited to form odour-place associations and guide olfactory-cued spatial navigationĮzenwa, Vanessa O., Sarah A. Ensembles of piriform neurons concurrently represented odour identity as well as spatial locations of animals, forming an odour-place map. The accuracy of spatial information carried by individual piriform neurons was predicted by the strength of their functional coupling to the hippocampal theta rhythm. Piriform spatial representations have features of a learned cognitive map, being most prominent near odour ports, stable across behavioural contexts and independent of olfactory drive or reward availability.
Here, using neural ensemble recordings in freely moving rats performing an odour-cued spatial choice task, we show that posterior piriform cortex neurons carry a robust spatial representation of the environment. Primary olfactory (piriform) cortex is thought to be the main cortical region for encoding odour identity. 595-599.Ībstract: Odours are a fundamental part of the sensory environment used by animals to guide behaviours such as foraging and navigation. “ Spatial Maps in Piriform Cortex During Olfactory Navigation.” Nature, vol. Poo, Cindi, Gautam Agarwal, Niccolò Bonacci, and Zachary F.